Motoneuron excitability and muscle spasms are regulated by 1 5 - HT
نویسندگان
چکیده
Motoneuron excitability and muscle spasms are regulated by 1 5-HT2B and 5-HT2C receptor activity. 2 3 Katherine C. Murray, Marilee J. Stephens, Edmund W. Ballou, Charles J. Heckman, 4 and David J. Bennett 5 Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada; Department of Physiology, 6 Northwestern University, Chicago, IL, USA. 7 8 9 Running Title: 5-HT2B receptors on motoneurons 10
منابع مشابه
Motoneuron excitability and muscle spasms are regulated by 5-HT2B and 5-HT2C receptor activity.
Immediately after spinal cord injury (SCI), a devastating paralysis results from the loss of brain stem and cortical innervation of spinal neurons that control movement, including a loss of serotonergic (5-HT) innervation of motoneurons. Over time, motoneurons recover from denervation and function autonomously, exhibiting large persistent calcium currents (Ca PICs) that both help with functiona...
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Adrenergic receptors modulate motoneuron excitability, sensory synaptic 1 transmission and muscle spasms after chronic spinal cord injury. 2 Rank MM, Murray KC, Stephens MJ, D’Amico J, Gorassini MA, and Bennett DJ 3 Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada 4 5 6 Running Title: Adrenergic receptors modulate spasms. 7
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The brain stem provides most of the noradrenaline (NA) present in the spinal cord, which functions to both increase spinal motoneuron excitability and inhibit sensory afferent transmission to motoneurons (excitatory postsynaptic potentials; EPSPs). NA increases motoneuron excitability by facilitating calcium-mediated persistent inward currents (Ca PICs) that are crucial for sustained motoneuron...
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Sensory afferent transmission and associated spinal reflexes are normally inhibited by serotonin (5-HT) derived from the brain stem. Spinal cord injury (SCI) that eliminates this 5-HT innervation leads to a disinhibition of sensory transmission and a consequent emergence of unusually long polysynaptic excitatory postsynaptic potentials (EPSPs) in motoneurons. These EPSPs play a critical role in...
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Motoneuron hyperexcitability is a characteristic of several different motor disorders. We examined neuronal mechanisms of hyperexcitability in two of these disorders: spasticity after spinal cord injury (SCI) and bruxism. Involuntary muscle spasms after SCI occur as a result of uncontrolled increases in motoneuron excitability. Brainstem-derived serotonin (5HT) and noradrenaline (NA) normally f...
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